Things in life can make us feel like we need to keep our focus there. They may appear significant because of the resources and source of life they bring. But the truth is, God needs to be the main focus. From him is where our direction should flow. No thing or thing we are apart of should be directing our lives, emotions, actions, or anything else.
God should matter too much to allow anything to come before him and a heart check will allow us to see where exactly we are in the process. Talents and abilities are not more important than him. Even helping people is not more important that keeping him the focus. Although, people many times are good at making you feel guilty whether perceived or self imposed.
If we keep him at the guide, then everything else is at most secondary. Those things are covered with what he wants to do with them and we are submitted underneath his authority.
We can do the most in our lives by making sure that our focus is him.